Product Name :
Propargyl-PEG1-acid
Description:
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM.
CAS:
55683-37-9
Molecular Weight:
128.13
Formula:
C6H8O3
Chemical Name:
3-(prop-2-yn-1-yloxy)propanoic acid
Smiles :
C#CCOCCC(O)=O
InChiKey:
GMFDYXLFHSFUHE-UHFFFAOYSA-N
InChi :
InChI=1S/C6H8O3/c1-2-4-9-5-3-6(7)8/h1H,3-5H2,(H,7,8)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM.|Product information|CAS Number: 55683-37-9|Molecular Weight: 128.13|Formula: C6H8O3|Chemical Name: 3-(prop-2-yn-1-yloxy)propanoic acid|Smiles: C#CCOCCC(O)=O|InChiKey: GMFDYXLFHSFUHE-UHFFFAOYSA-N|InChi: InChI=1S/C6H8O3/c1-2-4-9-5-3-6(7)8/h1H,3-5H2,(H,7,8)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Rifabutin manufacturer |Shelf Life: ≥12 months if stored properly.Thioridazine site |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32727291 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|BTK-CRBN PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of cereblon E3 ligases family recruitment.|References:|Tinworth CP, et al. PROTAC-Mediated Degradation of Bruton’s Tyrosine Kinase Is Inhibited by Covalent Binding. ACS Chem Biol. 2019 Mar 15;14(3):342-347.Products are for research use only. Not for human use.|
