The C-terminal two-thirds in the protein, which include two MA-3 domains that kind steady structures and enable tight interaction with eIF4A,250 the function in the N-terminal domain of Pdcd4 is…
May 2021
Ression interactions domainsComputational analysisProtein-by-proteintext miningData integrationprotein/gene sets p-valuesmodulesTP0658 FliW Treponema pallidium interactdata 1 data two datanetworksMS raw information m/zmodule A module B module CFunctional modulesGene/protein sets databaseKnown effect of toxinBiological…
ICCA cell lines also as inside a novel mouse iCCA preclinical model characterized by the concomitant activation of K-RasG12D mutant allele and overexpression of an activated/cleaved kind of Notch1 (NICD)…
Ndicated making use of Lipofectamine 2000 (Invitrogen). Right after 48 h, cells have been harvested. Firefly luciferase activities have been determined working with the Luciferase assay method kit (Promega, Madison,…
Driven iCCA improvement in vivo.Treatment using the MEK inhibitor PD901 results in steady illness in K-Ras/NICD miceHaving established a K-Ras-driven iCCA model, we next investigated the potential therapeutic activity of…