|IKK IκB [inhibitor of NF-κB (nuclear factor κB)] kinase family plays a indispensable role in innate immunity by inducing NF-κB- and IRF [IFN (interferon) regulatory factor]-dependent gene transcription programmes required for the production of pro-inflammatory cytokines and IFNs. A study from Kristopher CLARK discovered and identified MRT67307 as a novel inhibitor of IKKε/TBK1 (TANK TRAF [TNF (tumour-necrosis-factor)- receptor-associated factor]-associated NF-κB activator-binding kinase 1). The authors also used it to study the molecular mechanisms that activate these protein kinases and their complement of physiological substrates.||Firstly, in the study, MRT67307 prevented the phosphorylation of IRF3 and the production of IFNβ in macrophages. However, MRT67307 no longer suppressed the activation of JNK or p38 MAPK by poly(I:C) or other agonists.|Additionally, MRT67307 actually enhances phosphorylation in IKKα−/− MEFs, the IL-1-stimulated phosphorylation of p105 at Ser933 and RelA at both Ser468 and Ser536. MRT67307 also enhanced IL-1-stimulated activation of NF-κB-dependent gene transcription in wild-type MEFs.|Furthermore, in another study, MRT67307 (10 μM) was sufficient to reduce phospho-ATG13 to control levels, and in line with the in vitro IC50 values, 10-fold less MRT68921 (1 μM) results in a similar reduction.Venetoclax References |Besides, MRT67307 increased IL-10 production and suppressed proinflammatory cytokine production in macrophages.Adagrasib medchemexpress MRT67307 increased CREB-dependent gene transcription by promoting the dephosphorylation of CRTC3.PMID:34942624 MRT67307 did not inhibit the brain-specific kinases (BRSKs). And it only inhibited the maternal embryonic leucine zipper kinase (MELK) and AMPK itself more weakly.|To sum up, MRT67307 plays a significant role in innate immunology.|Reference:Clark K, et al. Biochem J. 2011 Feb 15;434(1):93-104. |Petherick KJ, et al. J Biol Chem. 2015 May 1;290(18):11376-83.MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use. We have professionally experienced and friendly staff to meet your needs. We are a competent and trustworthy partner for your research and scientific projects.Related websites: https://www.medchemexpress.com
