In addition, nutlin-3a induced p21 expression, an important mediator of p53dependent cell cycle arrest, 24 h after incubation, and it persisted 96 hours after treatment
As revealed in Figure 1E, U87MG cells showed a time-dependent increase of apoptosis induced by nutlin-3a (from three.3 to 27% at 24 and ninety six several hours, respectively) when compared…